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Plus, this drug has a completely novel mechanism of action and actually treats the cause of the pain instead of masking symptoms." "We are very pleased to see that TV1001sr completely eliminated the headaches associated with the immediate release formulation and extremely excited to see that our second Phase II study once again demonstrated strong and consistent clinical results in the reduction of pain," added Thera Vasc founder and CEO Dr. "In addition to diabetic neuropathy, we believe that there are many other conditions associated with chronic pain that could be treated with TV1001sr." Over 300 million people worldwide suffer from diabetes—a number that is expected to grow by over 50 percent by 2035.
Thera Vasc's medication uses sodium nitrite to treat diabetic pain by stimulating blood vessels.
Both fexofenadine and cetirizine are popular antihistamines with many similarities but there are some important differences. Second-generation antihistamines were first developed in the 1990s to provide allergy relief without the unwanted side effect of sedation common to first-generation antihistamines such as promethazine and diphenhydramine.
However, it soon became apparent that not all second-generation antihistamines were equal when it came to not causing drowsiness or affecting other thought processes.
"Patients also noted a decrease in overall and continuous pain scores by as much as 50 percent.
Pain reduction of this magnitude in patients with diabetic neuropathy is quite significant and better than a lot of current treatments.
No difference in side effects was noted between the two.
Allegra Vs Zyrtec for Postnasal Drip Post nasal drip may occur for various reasons - allergies (particularly to dairy), colds or flu, various drugs (including birth control pills and high blood pressure tablets), cold temperatures, bright lights, hormonal changes and spicy foods.
Allegra Vs Zyrtec for urticaria and other skin reactions All second generation antihistamines, including Allegra and Zyrtec, are effective for acute and chronic urticaria, although more trials have been conducted in people with chronic urticaria.
Intranasal antihistamines, such as azelastine, have a faster onset of action (15 minutes) and appear more effective than oral antihistamines although require more frequent administration.
Other treatments include decongestants, cromolyn, and corticosteroid nasal sprays.
Because of its mechanism of action, Thera Vasc's Clinical Advisory Board believes TV1001sr will ultimately provide benefit to patients with chronic pain resulting from a number of conditions associated with microvascular disease.
The company has future plans to conduct Phase III clinical studies in patients with systemic sclerosis, an autoimmune disease associated with microvascular damage in the hands, leading to severe pain and ulcers.